MOST IRRITATED can be described as a state of extreme annoyance or anger. This term can be broken down into two crossword solutions: SOREST (6 letters) and MADDEST (7 letters). SOREST is an adjective that means feeling physical pain or discomfort, while MADDEST is an adjective that means feeling extreme anger or rage. Both words describe a heightened level of irritation, making them suitable solutions for the term MOST IRRITATED.