The term 'most ironic' can be solved by two six-letter words: 'wriest' and 'wryest'. The word 'wriest' is an adjective meaning 'most writhing or contorted', while the word 'wryest' is an adjective meaning 'most dryly humorous or cleverly sarcastic'. Both words are used to describe something that is ironic, which is defined as 'the expression of one's meaning by using language that normally signifies the opposite, typically for humorous or emphatic effect'.