MOST DESPICABLE is a term used to describe someone or something that is considered to be the worst of its kind. The crossword solutions BASEST, VILEST, and SCALIEST all refer to this term. BASEST is an adjective meaning the lowest in rank or quality, while VILEST is an adjective meaning extremely wicked or loathsome. Finally, SCALIEST is an adjective meaning morally reprehensible or contemptible. All three words can be used to describe someone or something that is considered to be the most despicable.