The crossword solutions for the term 'MOST DEPRESSED' are 'LOWEST' and 'BLUEST'. LOWEST is a term used to describe the least amount of something, while bluest is a term used to describe the most intense shade of blue. Together, these two words can be used to describe someone who is feeling the most depressed, as depression is often associated with feelings of lowliness and sadness, which is often represented by the color blue.