UP' (4 letters) The crossword solutions for the term MIFFED, WITH 'UP' are FED and PUPP. The term MIFFED means to be annoyed or irritated. The word FED is an abbreviation of the verb 'to feed', which means to give food to someone or something. The word PUPP is an abbreviation of the noun 'PUPPY', which is a young dog. Therefore, the crossword solutions for the term MIFFED, WITH 'UP' can be interpreted as being annoyed or irritated with feeding a PUPPY.