The Midwest Region of the United States is comprised of states such as North Dakota, South Dakota, Nebraska, Kansas, Iowa, Missouri, Minnesota, Wisconsin, and Illinois. The two crossword solutions for the term 'Midwest Region' are 'Dakotas' (7 letters) and 'TheDakotas' (10 letters). The Dakotas refer to the two states of North Dakota and South Dakota, which are located in the Midwest Region of the United States.