The Midwest Indians are a group of Native American tribes that have inhabited the region for centuries. The Osages, Iowas, SACS, and Hurons are four of the most prominent tribes in this region. The Osages are a tribe of Native Americans who originally lived in the Ohio River Valley and later moved to the Great Plains. The Iowas are a tribe of Native Americans who traditionally lived in the area around the Mississippi River. The SACS are a tribe of Native Americans who traditionally lived in the Great Lakes region. The Hurons are a tribe of Native Americans who traditionally lived in the Great Lakes region and were known for their trading networks.