The term 'MIDDLE' can be described in a variety of ways. The crossword solutions for this term are PREF (5 letters), CENTR (5 letters), MEDIO (5 letters), and MESO (4 letters). PREF is an abbreviation for the word 'PREFERENCE, ' which means a person's inclination or choice. CENTR is an abbreviation for the word 'CENTRAL, ' which means being in the MIDDLE or center of something. MEDIO is a Spanish word meaning 'MIDDLE' or 'HALF.' Lastly, MESO is a Greek prefix meaning 'MIDDLE' or 'in between.'