The term 'man-mouse hook-up' refers to a type of computer connection that allows a user to control a computer with a mouse and keyboard. The acronym for this type of connection is ORA, which stands for 'Optical Remote Access'. This type of connection is used in many different applications, such as gaming, remote access, and virtual reality. It is a convenient way to control a computer from a distance, allowing users to interact with the computer without having to be physically present.