The crossword solution for the term 'Make the Best of' is 'Optimize'. Optimize means to make the most effective use of a situation or resource. It is often used in business and economics to refer to making the most efficient use of resources, such as time, money, energy, or materials. In other contexts, it can refer to making the most of a given opportunity or situation. Optimizing something can also mean finding the best possible solution to a problem.