The crossword solution for the term 'make lively, with 'UP'' is PEP. PEP stands for physical education and play, which are activities that can help to make people more lively and energetic. Physical education and play involve engaging in physical activities such as sports, exercise, and games, which can help to increase energy levels and improve overall health. Additionally, playing games and engaging in physical activities can also help to reduce stress and improve mental wellbeing.