The term 'MAKE IRATE' can be broken down into six crossword solutions: ENRAGE (6 letters), ANNOY (5 letters), VEX (3 letters), IRRITATE (8 letters), EXASPERATE (10 letters), and IRK (3 letters). All of these words refer to the act of making someone angry or frustrated. ENRAGE is the most intense of the six, suggesting a strong and sudden anger, while ANNOY and IRK are more mild and refer to a feeling of irritation. VEX and IRRITATE are similar in that they both suggest a feeling of frustration, but VEX is more likely to refer to a situation or problem that is causing the frustration, while IRRITATE is more likely to refer to a person or thing that is causing the frustration. Finally, EXASPERATE is the most extreme of the six, referring to a feeling of extreme annoyance or exasperation.