The term 'MAKE CHANGES IN A MANUSCRIPT' can be summarized by the crossword solution 'EDIT' (4 letters). Editing is the process of making changes to a manuscript in order to improve its quality and accuracy. This includes correcting grammar, spelling, punctuation, and other errors, as well as ensuring that the content is consistent and clear. It also involves making sure that the manuscript follows the style guide of the publication it is intended for.