The term 'make a difference to' can be summarized by two crossword solutions: AFFECT (6 letters) and MATTER (6 letters). AFFECT is a verb meaning to have an influence on something, while MATTER is a noun meaning something that is important or has significance. Both words are used to describe the idea of making a difference to something, whether it be a person, a situation, or an outcome. By making a difference to something, one is able to have an impact and make a lasting impression.