The term 'Major Pain' can be described by three words: HASSLE (6 letters), AGONY (5 letters), and PILL (4 letters). HASSLE is a word used to describe a situation that is difficult or annoying, often involving a lot of effort. AGONY is a word used to describe intense physical or mental suffering. PILL is a small, usually round object that is swallowed to take medicine or drugs. Together, these words can be used to describe a situation that is difficult, painful, and requires a lot of effort to overcome.