The term 'MAJOR NUISANCES' can be broken down into two crossword solutions: HEADACHES (9 letters) and MAJOR (5 letters). HEADACHES are a common medical condition that can range from mild to severe. They can be caused by a variety of factors, including stress, dehydration, and certain medications. MAJOR is an adjective that means important, significant, or influential. Together, the two words form the phrase 'MAJOR nuisances, ' which refers to something that is a MAJOR annoyance or disruption.