The term 'MAJOR EFFECT' can be summarized as a significant IMPACT or consequence. It is often used to describe the effects of a particular event, action, or decision. For example, a major effect of a natural disaster could be the destruction of homes and businesses. Similarly, a major effect of a policy change could be an increase in unemployment. In the crossword puzzle, the term 'MAJOR EFFECT' was solved with the word 'IMPACT, ' which is defined as a strong or major influence or effect.