The term 'Main Thoroughfare' is used to describe a major road or highway that is the primary route for traffic in an area. The two crossword solutions for this term are 'ARTERY' (6 letters) and 'Centralartery' (13 letters). An ARTERY is a large blood vessel that carries oxygenated blood away from the heart, while Centralartery is a combination of the words 'CENTRAL' and 'ARTERY', suggesting a main ARTERY or main thoroughfare.