The setting of the musical 'Little Shop of Horrors' is a florist shop called Mushnik's Skid Row Florists. It is located in a run-down part of an unnamed American city and is owned by Mr. Mushnik. The shop is staffed by the main character, Seymour Krelborn, and his love interest, Audrey. The shop is visited by various customers, including a sadistic dentist, Orin Scrivello. The musical follows the story of Seymour and Audrey as they try to save the shop from closing down.