The term 'Little Nothing' can be described by three crossword solutions: TWIT (4 letters), TRIFLE (6 letters), and TWERP (5 letters). TWIT is a slang term for a foolish or annoying person, while TRIFLE is an informal term for something of little value or importance. TWERP is another slang term for a silly or insignificant person. All three words describe someone or something that is insignificant, unimportant, or of little value.