The term 'Little Bump' can be solved by the crossword solution 'NODULE, ' which is a six-letter word. A NODULE is a small, solid lump that can form in various parts of the body, such as the skin, lungs, and thyroid. Nodules can be caused by a variety of factors, including inflammation, infection, and cancer. They can range in size from very small to large and can be either benign or malignant. Treatment for nodules depends on the cause and severity of the condition.