The term 'Like Man's Best Friend' can be summarized by two crossword solutions: 'LOYAL' (5 letters) and 'Fourlegged' (10 letters). This phrase is often used to describe the relationship between a human and their pet, usually a dog. Dogs are known for their loyalty and unconditional love, and they are also four-legged animals. This phrase is a way of expressing the strong bond between humans and their canine companions.