The crossword solution for the term 'Least Likely to Lose It' is SANEST, which is a six-letter word. Sanest is an adjective that means having or showing good judgment or common sense. It is often used to describe someone who is calm and composed in difficult situations and is not easily provoked. Therefore, the term 'Least Likely to Lose It' implies that the person is unlikely to become angry or agitated in stressful situations.