The crossword solutions for the term LEAD, OFTEN are HEROINE (7 letters) and TITLEROLE (9 letters). HEROINE is a term used to describe a female protagonist or main character in a story, while TITLEROLE is a term used to describe the leading role in a movie or play. Both terms refer to the same concept of a lead character, but HEROINE is more commonly used in literature, while TITLEROLE is more commonly used in film and theater.