Leno, a four-letter crossword solution for the term 'Late-Night Comedian, ' is the stage name of American comedian and television host, Jay LENO. He is best known for hosting NBC's The Tonight Show with Jay LENO from 1992 to 2009 and again from 2010 to 2014. LENO has been a staple in late-night television for decades, and is widely considered one of the most successful comedians in the history of the genre.