The largest US bank is CHASE, which has five letters. CHASE is a multinational financial services firm headquartered in Manhattan, New York City. It is the largest bank in the United States by assets and the sixth largest bank in the world. It is one of the Big Four banks in the United States, along with Bank of America, Citigroup, and Wells Fargo. CHASE offers a wide range of products and services, including consumer banking, corporate banking, investment banking, private banking, asset management, and wealth management.