The LIVER is the largest human gland, measuring up to 15 inches in length and weighing up to 3.5 pounds. It is located in the upper right quadrant of the abdomen and is responsible for a variety of functions, including detoxification, production of bile, and metabolism of fats, proteins, and carbohydrates. The LIVER also plays an important role in the immune system, producing antibodies and other substances that help fight infection.