The largest city of Nebraska is Omaha, which has five letters. Omaha is the largest city in the state of Nebraska and is located in the Midwestern United States. It is the county seat of Douglas County and is situated along the Missouri River. Omaha is the anchor of the Omaha-Council Bluffs metropolitan area, which includes Council Bluffs, Iowa, across the Missouri River from Omaha. The city is home to several Fortune 500 companies, including Berkshire Hathaway, Union Pacific Corporation, and ConAgra Foods.