Large dogs are a popular breed of canine, and there are many varieties to choose from. ALSATIAN, Mastiff, Towser, Great Dane, Irish Setter, Newfoundland, and Great Pyrenees are all examples of large dog breeds. ALSATIAN is an 8-letter breed that is also known as the German Shepherd. Mastiff is a 7-letter breed that is known for its large size and gentle nature. Towser is a 6-letter breed that is a cross between a Bulldog and a Mastiff. Great Dane is a 9-letter breed that is known for its large size and gentle demeanor. Irish Setter is an 11-letter breed that is known for its beautiful red coat and friendly personality. Newfoundland is a 12-letter breed that is known for its strength and loyalty. Finally, Great Pyrenees is a 13-letter breed that is known for its thick white coat and protective nature.