The crossword solution for the term 'Lake by Buffalo' is Erie, which is a four-letter word. Erie is the fourth-largest lake of the five Great Lakes in North America and is located on the international border between the United States and Canada. It is the southernmost of the Great Lakes and is named after the Erie tribe of Native Americans who lived along its southern shore. The lake is connected to Lake Ontario by the Niagara River and is bordered by the cities of Buffalo, New York and Erie, Pennsylvania.