The term 'Lake Erie' is the answer to the crossword puzzle clue 'Lake at one end of the Niagara River'. Lake Erie is the fourth largest of the five Great Lakes in North America and is located on the border between the United States and Canada. It is the southernmost, shallowest, and smallest by volume of the Great Lakes. The Niagara River flows into Lake Erie from Lake Ontario, and the outflow from Lake Erie is the Niagara River, which flows over Niagara Falls and into Lake Ontario.