The term 'Lady of the Casa' is a title given to a woman who is in charge of a household. The two crossword solutions for this term are 'Dona' (4 letters) and 'SENORA' (6 letters). Dona is a Spanish title of respect given to a woman, while SENORA is a Spanish title of respect given to a married woman. Both titles are used to refer to the Lady of the Casa, who is responsible for managing the household and its occupants.