The term 'Lack of Get-up-and-Go' can be described by two crossword solutions: ANEMIA (6 letters) and INERTIA (7 letters). ANEMIA is a condition in which the body does not have enough healthy red blood cells to carry oxygen to the tissues. It is caused by a deficiency of iron, folate, or vitamin B12. INERTIA is the resistance of any physical object to any change in its state of motion, including changes to its speed and direction. It is the tendency of an object to remain at rest or in uniform motion in a straight line unless acted upon by an external force. Together, these two terms describe a lack of energy or motivation.