The term 'La Crosse, Wisconsin' refers to a city located in the southwestern corner of the state. It is situated along the Mississippi River and is the largest city on the river between Minneapolis and St. Louis. La Crosse is known for its vibrant downtown area, which features numerous shops, restaurants, and attractions. The city is also home to the University of Wisconsin-La Crosse, as well as several other colleges and universities. La Crosse is a popular destination for outdoor recreation, with numerous parks, trails, and waterways.