The crossword solution for the term 'LA ___, WIS.' is 'CROSSE'. La Crosse is a city in Wisconsin located along the Mississippi River. It is the county seat of La Crosse County and is the largest city on Wisconsin's western border. The city is home to the University of Wisconsin-La Crosse and Viterbo University. La Crosse is known for its vibrant downtown area, which features a variety of restaurants, shops, and entertainment venues.