Klondike is a region in the Yukon Territory of Canada, which was the site of a major gold rush in the late 19th century. The term 'Klondike' is often used to refer to this period of history and the people who lived through it. The crossword solution for the term Klondike is KATE, which is likely a reference to the famous Canadian author and adventurer, KATE Carmack, who was one of the first to discover gold in the area.