Keep Locked Up is a phrase that is often used to describe the act of keeping something secure and out of reach. The term can be used to refer to physical objects, such as a CLOSET, or to intangible items, such as confidential information. In this case, the crossword solution for Keep Locked Up is CLOSET, which is a storage space typically used to store items that are not in use. Closets are often locked to keep the contents secure and out of reach.