The term 'It's in Vein' is a phrase that is used to describe something that is not worth the effort. It can be used to describe a situation where someone has put in a lot of effort but has not seen any results. The two crossword solutions for this term are 'BLOOD' and 'LODE'. BLOOD is a red liquid that circulates through the body and is composed of plasma, red and white BLOOD cells, and platelets. A LODE is a vein or deposit of ore, typically found in a rock formation.