The term 'It's a Sign' can be represented by six different crossword solutions: LEO (3 letters), ARIES (5 letters), LIBRA (5 letters), OMEN (4 letters), CUE (3 letters), and HARBINGER (9 letters). LEO is the fifth astrological sign of the zodiac, which is associated with the constellation LEO. ARIES is the first astrological sign of the zodiac, which is associated with the constellation ARIES. LIBRA is the seventh astrological sign of the zodiac, which is associated with the constellation LIBRA. An OMEN is an event or occurrence that is believed to portend a good or bad future event or circumstance. A CUE is a signal or prompt to do something. A HARBINGER is a person or thing that foreshadows or anticipates the coming of another. All of these words are related to the idea of signs, either in the literal sense or in the figurative sense.