The term IT MAY BE PICKED UP OR LET OFF can be solved by the crossword clue STEAM (5 letters). STEAM is a type of energy that is created when water is heated to its boiling point and turns into vapor. It is often used to power machines, such as locomotives, turbines, and ships. STEAM can also be used to heat buildings and provide hot water for showers and baths. In this context, the phrase IT MAY BE PICKED UP OR LET OFF could refer to STEAM being used to power a vehicle or machine, which can be picked up or let off at various locations.