The crossword solution for the term 'IT MAY BE LOST' is 'CAUSE', which is a five-letter word. The term 'CAUSE' can refer to a number of different things, including the source of an event or action, a justification or motive for something, or a person or thing that produces an effect. It can also refer to a legal principle or a charitable organization. In general, the term 'CAUSE' is used to describe something that leads to a particular result.