The term 'It Has a Twin City in the Midwest' can be solved by the word 'Urbana', which is a 6-letter word. Urbana is a city located in Champaign County, Illinois, United States. It is the twin city of Champaign, and together they are known as the Champaign-Urbana metropolitan area. Urbana is home to the University of Illinois at Urbana-Champaign, and it is known for its vibrant cultural and artistic community.