An irritating skin sensation, commonly referred to as an ITCH, is a common symptom of many skin conditions. It is caused by the release of histamine and other chemicals from nerve endings in the skin. Itching can be localized or generalized, and can range from mild to severe. It can be accompanied by redness, swelling, and burning sensations. Treatment for itching depends on the underlying cause, but may include topical creams, oral medications, and lifestyle changes.