The term 'Irksome Ones' can refer to three different things: Pills (5 letters), Nagging (4 letters), and PESTS (5 letters). Pills are small, usually round tablets that contain medicine or other substances. Nagging is the persistent and often annoying act of asking someone to do something. PESTS are animals or insects that cause damage to crops, property, or health. All three of these things can be very irritating and can cause frustration.