The crossword solution for the term 'IOWA STATE CITY' is 'AMES', which is a four-letter word. AMES is a city located in the central part of the U.S. state of Iowa. It is the county seat of Story County and is located approximately 30 miles north of Des Moines, the state capital. AMES is the home of Iowa State University, which is the largest university in the state. The city was founded in 1864 as a station stop on the Cedar Rapids and Missouri Railroad and was named after 19th century U.S. Congressman Oakes AMES of Massachusetts.