The crossword solutions for the term INVIGORATE WITH 'UP' are PEP and JUICE. PEP is an acronym for Positive Emotional Power, which is a concept that encourages people to use positive emotions to increase their motivation and energy levels. JUICE is a slang term for a beverage made from fruits or vegetables, usually WITH added sugar or other sweeteners. Both PEP and JUICE can be used to INVIGORATE oneself, as they provide a boost of energy and can help to improve mood.