The Inca Empire was a large pre-Columbian civilization that flourished in South America from the 12th to 16th centuries. The capital of the Inca Empire was CUZCO, which is also known as Cusco or CuzcoPeru. CUZCO is a city in southeastern Peru, located in the Andes mountain range. It is one of the oldest continuously inhabited cities in the Americas and was declared a World Heritage Site by UNESCO in 1983.