In spite of is a phrase used to express that something happened or is true despite the fact that something else happened or was true. It is often used to express that something happened in spite of difficulties or opposition. The crossword solutions for this phrase are ALTHOUGH (8 letters), NOTWITHSTANDING (15 letters), AFTER (5 letters), and REGARDLESS (10 letters). All of these words have similar meanings to in spite of, but they are used in different contexts. ALTHOUGH is used to introduce a clause that expresses a contrast with what has already been stated, NOTWITHSTANDING is used to emphasize that something will happen or is true despite any difficulties or opposition, AFTER is used to indicate that something happened or is true AFTER something else, and REGARDLESS is used to emphasize that something will happen or is true regardless of any other factors.