The term 'in and of itself' is a phrase that is used to emphasize the importance or uniqueness of something. The crossword solutions for this phrase are ALONE (5 letters), PERSE (5 letters), and ASSUCH (6 letters). ALONE means by itself, without any other people or things; PERSE means to persist in a course of action despite difficulty or opposition; and ASSUCH means as such, in the same way. Together, these words can be used to describe something that is unique and stands on its own, without needing any additional support.