The term 'I, in Ithaca' can be solved by two crossword solutions: IOTAS and IOTA. IOTAS is a five-letter word meaning 'the ninth letter of the Greek alphabet, ' while IOTA is a four-letter word meaning 'a very small amount.' Both words are derived from the Greek letter IOTA, which is the smallest letter in the Greek alphabet. The term 'I, in Ithaca' is a reference to Homer's Odyssey, in which Odysseus returns to his home in Ithaca after his long journey.